According to experts at Healthline, there are a few signs of selenium deficiency to look out for. Selenium is also a part of the enzymes that deiodinate thyroid hormones. Brittle Nails - Selenium toxicity can cause changes to your nail beds including discoloration in your nails. Leukonychia and Terry-like nails have been reported. Serious side effects of Selenium. It is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection (Sundee et al Modern nutrition in Health and Disease 11th Ed. Crab, fish . Selenium deficiency was linked to cardiomyopathy, which is a chronic disease of the heart muscle. The daily upper limits for selenium include intakes from all sourcesfood, beverages, and supplementsand are listed below. Generally, selenium acts as an antioxidant that works with vitamin E. Some epidemiologic studies associate low . This is also a symptom because the deficiency causes loss of thyroid function, which is accompanied by tiredness. People dependent on food grown from selenium-deficient soil may be at risk . Selenium deficiency is very rare in the United States and Canada. It is weak and reluctant to move. The calf may stand and move stiffly. Many studies have investigated the immune damage caused by Se deficiency in chickens, but its mechanism still needs to be explored. Furthermore horses . Selenium deficiency could exacerbate iodine deficiency, potentially increasing the risk of cretinism in infants [ 2, 5 ]. Patients with phenylketonuria or other diet-related diseases are prone to selenium deficiency because their diet is restricted from foods rich in selenium. These include: infertility in men and women impaired thyroid function muscle weakness fatigue brain fog hair loss weakened immune system (getting sick often, suffering from autoimmune conditions) Selenium deficiency is responsible (either alone or together with vitamin E deficiency) for many of the cases of WMD ("white muscle disease"), evidenced at slaughter or during necropsy by whitish appearance of striated muscle tissue due to bleaching by peroxides and hydroperoxides. Selenium Deficiency in Adult Dairy Cattle. A deficiency of selenium in growing chickens causes exudative diathesis. Additionally there can be other reasons: due to its function in the organism it is responsible for the reduction of toxic substances. It might also cause Kashin-Beck disease, a type of arthritis that produces pain, swelling, and loss of motion in your joints. Selenium deficiency occurs in patients receiving parenteral nutrition, in areas where soil selenium content is poor, in cirrhosis patients with ineffective metabolism of selenomethionine, and in low-birth-weight infants. Fatigue - Due to selenium's role in turning food into energy and aiding your metabolism, selenium deficiency can cause you to feel tired and fatigued. Selenium (Se) is now recognised as an essential trace element for ruminants. In areas where there is enough selenium in the soil, goats can suffer from secondary selenium deficiency if they are consuming too much sulfur. However, selenium deficiencies are quite rare. When it occurs . glutathione peroxidase) due to low selenium status. Another disease associated with selenium deficiency is Kashin-Beck disease. Selenium occurs in all tissues. Selenium deficiency can also cause stiffness, even mild lameness, and disturbances of the entire metabolism. Based on the biochemical relationships of ascorbate and selenium, simultaneous nutritional deficiencies of them would be expected to impose a severe stress on the . Low selenium state has been associated with depressed mood, anxiety, and confusion. Treating selenium deficiency safely. Zinc: Zinc deficiency can cause similar hair loss to iron and may also damage any remaining hair, causing it to break. Causes. Selenium deficiency is rare and is caused by consuming too little of the mineral selenium. Subacute muscular dystrophy, also known as white muscle disease, is the most commonly seen form of selenium deficiency in calves. Moderate deficiency plays a role in myodegenerative diseases, such as muscle weakness. The disease causes joint degeneration in children and can cause dwarfism. They may also abort or not become pregnant at all. environmental toxins. It is required for growth and to aid resistance to diseases, being involved in the production of antibodies and in the killing of micro-organisms engulfed by macrophages. Selenium deficiency may cause cardiomyopathy post-gastric bypass. Low selenium is more likely to affect people who: Are malnourished Have undergone gastric bypass Selenium deficiency can result in nonspecific symptoms like fatigue and brain fog. Sheep, goats, and cattle who eat a diet with selenium and vitamin E deficiency may develop a condition called white muscle disease in which the muscles degenerate from oxidative damage.Worldwide, between 500 million and 1 billion people have selenium deficiency . At the molecular level, it seems that the best explanation for cardiomyopathy secondary to selenium deficiency is that selenium deficiency causes myopathy as a result of the depletion of GPx and TRxR that protect cardiomyocytes from oxidative damage. Telogen effluvium isn't a complicated condition, but it requires some . Selenium is needed for the immune system to work properly. . A deficiency of selenium in the U.S. is rare as the soil throughout North America is generally rich in selenium. The selenium deficiency is curable and sometimes incurable (if the horse owner shows reckless behaviour). Although Selenium deficiency has several ill effects, it can be treated with the right consultation and medical supplements as prescribed by medical experts however, a high . Selenium is not produced in the body, but it is needed for proper thyroid and immune system function. #7. [7] Even if people live in areas with lower-selenium soil, the transport of food across the region as well as the use of fortified foods and supplements reduce the risk of deficiency. Symptoms Of Selenium Deficiency [2] Infertility in men and women Hair loss Muscle weakness Brain fog Weakened immune system Fatigue Who Is At The Risk Of Selenium Deficiency? These promote healthy hair growth, and those with selenium deficiency may experience hair loss. Selenium Deficiency. This is also a sign of iron deficiency, and you may be recommended energy supplements. According to a 2018 article, excessive selenium can actually both modify the hair's structure as well as impair the hair cycle, causing a condition called telogen effluvium. Selenium deficiency is a problem in a large portion of the United States. Selenium occurs in all tissues. Ge K, Yang G. The epidemiology of selenium deficiency in the etiological study of endemic diseases in China. These results indicated that Se deficiency induced ER stress and increased the apoptosis in swine small intestine and IPEC-J2 cells and then caused the damage in swine small intestinal tissue. Selenium deficiency does not usually cause overt clinical injury but it predisposes animals to damage by vitamin E deficiency, certain viral infections, and some chemicals [7, 8]. Abstract. In addition, a drop in performance is also often noticed. [ ref] Both of these diseases are thought to be the result of decreased antioxidants (e.g. Selenium. Selenium deficiency adversely affects the functioning of the cardiovascular system and is the direct cause of myocardial infarction. Many of the symptoms are therefore the same as those of an underactive thyroid:10,11 hair loss or changes to hair and nails fatigue brain fog , difficulty concentrating or memory problems Philadelphia PA Lippincott, Williams and . Signs in the horse included hair loss from mane and tail, sloughing of hooves, joint . Selenium (Se) is a vital mineral for the human body to work as an antioxidant and fighting the aging process by improving immunity and lowering the damage that happens by the free radical, Selenium enhancing the body's resistance against stress, infection, and diseases. 1993; 57:259S-263S. What is Selenium and How Does it Work in the Body? Selenium deficiency can cause Keshan disease (a type of heart disease) and male infertility . What causes elevated selenium levels? What are the top selenium deficiency symptoms, and what foods contain selenium? Deficiency may cause mood imbalances 1, and can contribute to a higher risk of developing diseases like cancer, and rheumatoid arthritis 3. This can also be a symptom of vitamin C deficiency. Your body only needs a trace of selenium, as too much can cause brittle nails, hair loss, skin rashes, fatigue, and irritability. #2. Selenium deficiency can surface in the form of muscle weakness, anxiety, depressed mood, and confusion. There are several suspected causes of Keshan disease, including: selenium deficiency. Here's what you need to know. The common noticeable symptoms of selenium deficiency are sore muscles, poor performance, trembling or Muscle Spasms, stiff gait, tying up, respiratory distress, difficulty in suckling, and impaired movement, etc. While the RDA for selenium for adults is 55 micrograms/daily, the average daily intake in the U.S. is believed to be 125 micrograms per day, far more than the recommended daily amount. An excess of selenium can be toxic. If selenium is low it may result in a foggy state of mind, but it usually occurs coupled with other symptoms. Extremely high intakes of selenium can cause severe problems, including difficulty breathing, tremors, kidney failure, heart attacks, and heart failure. The edema results in weeping of the skin, which is often seen on the inner surface of the thighs and wings. Low selenium causes the muscular degeneration known as white muscle disease which can be severe and fatal to newborn foals In mild cases with adult horses you will see a depressed immune system, increasing the likelihood of disease and decreased fertility in breeding stallions and mares. Before treating your flock for selenium deficiency, it's important to be sure of the diagnosis. There is a narrow therapeutic window for selenium, which can become toxic if the doses are exceeded. selenium concentrations were 1.58 mol/L and 1.56 mol/L, respectively. The most common ones are: infertility in men and women muscle weakness fatigue mental fog hair loss weakened immune system Who's at risk? Selenium deficiency is rare and is caused by consuming too little of the mineral selenium. Am J Clin Nutr. 1. Selenium can indeed cause hair loss and hair brittlenesstwo major issues for your mop. Causes of selenium deficiency Most cases of selenium deficiency are caused by not consuming enough of this mineral in your diet. It is required in cattle for normal growth and fertility and for helping to prevent other health disorders such as mastitis and calf scours. Some contributing causes to a deficiency can include: Not eating selenium foods very often. Early signs of unthriftiness and ruffled feathers usually occur at 3-6 wk of age, depending on the degree of deficiency. Cows may not expel the placenta in a timely manner if they are deficient in selenium. How Selenium Deficiency Can Trigger Hashimoto's. It can be a bit complicated, but it's worth spending a few minutes talking about how a deficiency in selenium can be a trigger for Hashimoto's. It's also important to understand the iodine piece of this, as high levels of iodine can increase the risk for selenium deficiency. A slight deficiency often leads to an impaired immune response to infections or an increased tendency to allergies. Serum selenium concentrations difered by age, sex, race, ethnicity, poverty-income . Selenium Deficiency | Dietary Sources, Causes, Signs & Symptoms, Diagnosis, TreatmentSelenium is an essential trace mineral required for a variety of process. What are the symptoms of selenium deficiency? Selenium is an essential nutrient trace element for the body and has important biological functions. Alkali disease of horses and cattle was shown to be caused by selenium. Selenium (Se) is a part of the enzyme glutathione peroxidase, which metabolizes hydroperoxides formed from polyunsaturated fatty acids. In this study, we fed 1-day-old Hyline male chickens with Se deficient di Selenium is an essential element for animals, but not plants. Selenium deficiency in cattle. Can Cause Cardiovascular Problems. Low levels of selenium cause a reduced production of thyroid hormone by the thyroid gland. Daily diet deficiency of selenium can adversely affect. Some horses may develop diarrhea or watery stools too. Some reasons for selenium deficiencies include drinking alcohol, smoking cigarettes, and taking birth control pills. Selenium deficiency causes rare diseases like Keshan which is related to the function of the heart and Kashin-Beck disease which is associated with cognitive impairment. Furthermore, the French study showed that, over a nine-year period, decline in cognitive ability was associated . Selenium is an essential trace mineral found in soil, water, and some foods. It helps protect cells against damage by free radicals, which are reactive by-products of normal cell activity. Hair Loss - Selenium deficiency can also cause hair loss which means many people with hair loss use selenium. Some of the risk factors for developing a selenium deficiency include: Intestinal, digestive, or absorption issues like Crohn's disease Having had gastric bypass surgery Living in an area with selenium-deficient soil Undergoing kidney dialysis Having human immunodeficiency virus (HIV) Symptoms Manifestations in children include hypopigmentation of the skin and hair (pseudoalbinism). A selenium deficiency could cause you to develop Kashin-Beck disease, a joint and bone disorder that is geographically concentrated in parts of central China, eastern Siberia, and northern Korea. It makes the water stinky and unpalatable for more people. In pigs, Selenium deficiency can also cause liver degeneration. A French study of 1166 adults aged 60 - 70 years showed greater cognitive decline in individuals with selenium levels below 75.8 micrograms per liter as compared with individuals with selenium levels above 86.9 micrograms per liter. Get emergency help immediately if any of the following symptoms of overdose occur while taking selenium: Symptoms of overdose. However, if given in too large a dose or more than one supplement containing selenium is given at . By itself, selenium deiciency does not usually cause illness. Brain Fog. Selenium deficiencies can occur when the blood isn't able to properly absorb selenium. Hair loss - This vital mineral is responsible for activating an enzyme which is essential for the making of antioxidants in the body. Selenium was first identified as a toxin in the 1930s. Selenium is used to treat or prevent selenium deficiency. Signs of Deficiency and Toxicity Deficiency. The role of selenium in cancer treatment is still under study. Selenium deficiency can produce a range of symptoms. Selenium deficiency is one of the most common nutritional deficiencies in beef cattle in California 1. Rather, it can make the body more susceptible to illnesses caused by other nutritional, biochemical, or infectious stresses . Just be sure that your dose isn't too high or you may cause the same problem. It is an important factor in many body processes. These symptoms, if ignored, can lead to more complicated health risks ( 1 ). Skeletal muscle disorders associated with selenium deficiency in humans Skeletal muscle disorders manifested by muscle pain, fatigue, proximal weakness, and serum creatine kinase (CK) elevation have been reported in patients with selenium deficiency. Other trace elements and nutritional deficiencies can also cause poor growth rates and infertility so self-diagnosing selenium deficiency is not advised. The most common selenium deficiency symptoms include: reproductive issues muscle weakness fatigue brain fog thyroid dysfunction mood-related issues including depressed mood, anxiety and hostile behaviors hair loss weak, brittle nails susceptibility due to illnesses due to a weakened immune system confusion and cognitive changes Selenium deficiency is closely associated with the development of several diseases and impairment of physiological functions, such as that selenium deficiency causes cardiomyopathy, Creutzfeldt-Jakob disease [1, 2], and Kaschin-Beck disease [].In addition, selenium deficiency increases the risk . Iodine deficiency can cause an array of symptoms: an enlarged thyroid, poor growth, reduced milk production, pregnancy toxemia, reproductive abnormalities, and infertility to name a few. Selenium works with vitamin E as an antioxidant. seasonal changes. Weak muscles are also a sign of vitamin D deficiency. Protein energy malnutrition (PEM) has been rarely documented as a cause of cardiovascular abnormalities, including dilated cardiomyopathy. Selenium is responsible for antioxidant defense mechanisms in cardiomyocytes, and its deficiency in the setting of PEM and disease related malnutrition (DRM) may lead to exacerbation of the dilated . Diarrhea The etiology of RLS is not precisely defined yet but it may be primary (idiopathic) or secondary. It can cause diarrhea, reduced weight gain/loss of weight and can cause vaccines to be less effective 2. Symptoms of selenium deficiency include fatigue, difficulty concentrating, and hair loss. It helps protect cells against damage by free radicals, which are reactive by-products of normal cell activity. Individuals who are deficient in selenium may exhibit slow wound healing as a symptomatic manifestation of their condition. You May Like: What Is . [16] (2012, October 22). Selenium: Armani cautions that selenium deficiency is rare. Selenium deficiency causes serious problems. Besides, the results of gene expressions in our experiment proved that ER stress induced by Se deficiency promoted apoptosis. Magnesium deficiency is a major biochemical cause of hair loss in women. Selenium deficiency is known to cause problems for many systems of the body including the cardiovascular system, the immune system and the endocrine system. Although research is . Several deficiencies cause fatigue, including selenium deficiency. Selenium increases antioxidant effects in the body. This can happen on some farms that have well water. Referring to this vets advise to feed selenium if a horse ate cadmium, lead, tin or mercury. Research has shown that the elderly with low . 12 Symptoms of the disease include: Advertisements Stunted growth in children Multiple joint damages, deformed joints, enlarged joints Dwarfism Selenium deficiency is extremely rare in healthy, well-fed individuals. As already explained fodder with a lack of minerals (selenium) often causes a selenium deficiency. Selenium works with vitamin E as an antioxidant. Selenium deficiency manifests itself much differently in adult animals. Thyroid hormone helps with expediting the process of skin barrier formation by stimulating the activity of certain enzymes. . Other Mineral Deficiencies (Magnesium, Calcium, Iron, Copper, and Zinc) Retrieved October 10, 2022 from www.sciencedaily.com . American College of Gastroenterology (ACG). Although not all of these side effects may occur, if they do occur they may need medical attention. Instead of muscle degeneration, weakness and death, Selenium-deficient adults tend to have chronic infections and reproductive problems. Selenium may help protect against some cancers. viral or fungal infection. BoSe . Selenium has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol. Selenium deficiency can cause epiphyseal plate lesion and decrease cartilage type II collagen production. Thus RLS is one of the most important causes of insomnia and sleepiness during the day. Who is at risk for selenium deficiency? Get Dr.Berg's Trace Minerals Enhanced Supplemen. ScienceDaily. Selenium may help protect against some cancers. The signs depend on the muscles affected. Between 10% to 40% of animals die of this condition ( Andrews A. H., 1992 ). It can occur in patients with severely compromised intestinal function, those undergoing total parenteral nutrition, those who have had gastrointestinal bypass surgery, and also in persons of advanced age (i.e., over 90). Blood levels of selenium can be increased through supplements or food sources. But it can also cause severe issues like infertility and heighten the effect of certain viruses if one gets infected. [Google . The mechanism of selenium toxicity is still not clear but the blocking of sulfur uptake and use within the cells is a likely prospect. Along with its needed effects, selenium may cause some unwanted effects. Selenium deficiency is also associated with male infertility and might play a role in Kashin-Beck disease, a type of osteoarthritis that occurs in certain low-selenium areas of China, Tibet, and Siberia [ 1, 2, 5, 6, 8, 22 ]. Selenium (Se) is an essential trace element and its deficiency can lead to immune dysfunction. It affects the thyroid, metabolism, the heart, nervous system, muscular-skeletal system, digestive system and more. Causes. According to a study published in the journal Biomedical and Environmental Sciences, oral supplementation of selenium may reduce your risk of cancer 5. malnutrition. The dietary requirement of cattle is 0.05 to 0.1 mg Se/kg. You don't have to get your well water tested to know if you have sulfur. 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